Pardon Our Dust

We are doing a major system upgrade. Therefore, the ASA Education Center will not be available starting at 4 p.m. CDT on Wednesday, July 29,through Sunday, August 2. You will be able to access and continue with your courses on Monday, August 3. We apologize for any inconvenience.



Purchase Course & Materials

Course Fee
Member price: $0.00
Non-member price: $20.00

This course is a part of ANESTHESIOLOGY Journal CME 2014 Annual Subscription

Course Description

Member price: $0.00, Non-member price: $20.00

"Mechanical Ventilation–associated Lung Fibrosis in Acute Respiratory Distress Syndrome: A Significant Contributor to Poor Outcome,” by Cabrera-Benitez et al., pp. 189-198


There is increasing evidence suggesting that mechanical ventilation, which is necessary for life support in patients with acute respiratory distress syndrome (ARDS), can cause lung fibrosis, which may significantly contribute to morbidity and mortality. The role of mechanical stress as an inciting factor for lung fibrosis is not well understood. In this month’s Journal CME selection, the authors of the review article explore advances in pulmonary fibrosis in the context of ARDS, concentrating on its relevance to the practice of mechanical ventilation. The idea that mechanical ventilation—or more specifically, that ventilator–induced lung injury—may be a major contributor to lung fibrosis is a primary focus. Potential therapeutic strategies to mitigate this fibrosis are also discussed.
The focus of ANESTHESIOLOGY Journal CME is to educate readers on current developments in the science and clinical practice of anesthesiology.

Learning Objectives:

After completing this activity, the learner will be able to:

  • Cite the risk factors associated with mechanical ventilation and pulmonary fibrosis
  • Recognize the paradoxical (beneficial vs. exacerbating) effects of mechanical ventilation in the treatment of acute respiratory distress syndrome (ARDS)
  • Appropriately select patients most likely to benefit from corticosteroids administration during treatment of ARDS

Faculty & Credentials:

Editor-in-Chief: James C. Eisenach, M.D., receives consulting fees from Adynxx, NeuroGesX, and Vertex.

CME Editors: Leslie C. Jameson, M.D., receives honoraria from Masimo and honoraria from GE Medical International. Dan J. Kopacz, M.D., has ownership in Solo-Dex LLC.

Authors: Arthur S. Slutsky, M.D., receives consulting fees from Gambro Inc., Grobenzell, Germany; Maquet Medical, Solna, Sweden; Novalung GmbH, Heilbronn, Germany; GSK, Mississauga, Ontario, Canada; and Apeiron Biologics AG, Vienna, Austria. Nuria E. Cabrera-Benitez, Ph.D., John G. Laffey, M.D., Matteo Parotto, M.D., Ph.D.,
Peter M. Spieth, M.D., Ph.D., Jesús Villar, M.D., Ph.D., and Haibo Zhang, M.D., Ph.D., have reported no financial
relationships with commercial interests.

ASA Staff: Employees involved in planning have no financial relationships with commercial interests.

Resolutions of Conflicts of Interest

In accordance with the ACCME Standards for Commercial Support of CME, the American Society of Anesthesiologists will implement mechanisms, prior to the planning and implementation of this CME activity, to identify and resolve conflicts of interest for all individuals in a position to control content of this CME activity.


The information provided at this CME activity is for continuing education purposes only and is not meant to substitute for the independent medical judgment of a healthcare provider relative to diagnostic and treatment options of a specific patient’s medical condition.

Core Competencies:

Medical knowledge

Target Audience:

ANESTHESIOLOGY Journal CME is intended for anesthesiologists. Researchers and other health care professionals with an interest in anesthesiology may also participate.

CME Credit:

1.00 AMA PRA Category 1 Credit™

The American Society of Anesthesiologists is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

The American Society of Anesthesiologists designates this journal-based CME activity for a maximum of 1.00 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

1.00 Non-physician Credit

Non-physicians may receive a Certificate of Completion stating that this activity was designated for 1.00 AMA PRA Category 1 Credit(s)™.


Anesthesiology’s Journal CME is open to all readers. To take part in Anesthesiology Journal-based CME, complete the following steps:

  1. Read the CME information presented on this page.
  2. Register at Non-members will be asked to provide payment.
  3. Read this month’s article designated for CME credit available online within the activity.
  4. Achieve a score of at least 50% correct on the six-question online journal CME quiz and complete the evaluation.
  5. Claim credit in15-minute increments, for a maximum of 1 AMA PRA Category 1 Credit™ per journal article.

Required Hardware / Software:

Adobe Acrobat Reader, Internet connection, web browser version must have been released within the last three years.

Activity Release Date:

06/16/2014 - 9:00am

Activity Expiration Date:

06/16/2017 (All day)

Estimated Time to Complete:

60 minutes